Tetracyclines for malaria.
نویسندگان
چکیده
منابع مشابه
The tetracyclines.
The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
متن کاملTetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.
Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, the apicoplast and the mitochondrion, in cultured Plasmodium falciparum. Antimalarial effects were ...
متن کاملYeast Growth and Tetracyclines
COWLES, P. B. 1941 Germicidal action of hydrogen ion and of lower fatty acid. Yale J. Biol. Med., 13, 511-578. DOMIAGK, G. 1935 A new class of disinfectants. Deut. med. Woshschr., 61, 829-832. FRANK, H. G. AND REINER, L. 1954 The action of fat-acids on Trichomnonas vaginalis. J. Immunol., 72, 191-193. KEENEY, E. L. 1943 Fungistatic and fungicidal effect of sodium propionate on common pathogens....
متن کاملNeuroprotection by tetracyclines.
The neuroprotective properties of tetracyclines have been clearly established in rodent models of acute and chronic neurodegeneration during the past few years. Recent findings have provided novel insights into the molecular and cellular mechanisms of protection of neurons and oligodendrocytes by tetracyclines. These advances have prompted several clinical trials with minocycline, the most effe...
متن کاملRapid microbiological assay for chloramphenicol and tetracyclines.
An agar diffusion assay for chloramphenicol and tetracyclines is described, using inhibition of hemolysis by Clostridium perfringens as a biological indicator of antimicrobial activity. Well-defined zones formed after a 1.5- to 2-h incubation in an anaerobic chamber or after 3 h using a GasPak system. Serum levels of chloramphenicol as low as 2.0 mug/ml could be reproducibly determined with thi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1972
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5833.176-b